His death was announced on his official Instagram page.
He was surrounded by his family and full of love.
Phil brought immense joy to everyone around him and leaves behind a legacy of music and love.
Phil Lesh in 2009Cory Schwartz/Getty Images
We request that you respect the Lesh familys privacy at this time.
The Dead was inducted into The Rock and Roll Hall of Fame in 1994.
He often performed with his sons Grahame and Brian in a group he called the Terrapin Family Band.
In 2005, Lesh published his memoirSearching for the Sound: My Life with the Grateful Dead.
Lesh had suffered ill health over the years, including Hepatitis C and, in 2006, prostate cancer.
In more recent years he was treated for bladder cancer and underwent back surgery.
Complete information on survivors was not immediately available.