Even after its landmark twentieth season, Shonda RhimesGreys Anatomyalready has a Season 21 in the works.

Those curious about the 21stseason of the medical show can read everything we know below.

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Season 21 arrives September 26 at 10 p.m. on ABC.

‘Grey’s Anatomy’

Grey’s Anatomy: Brett Tucker, Jake Borelli, Kelly McCrearyMitch Haaseth/Disney General Entertainment Content via Getty Images

Theshows renewalcame about in April 2024.

How many episodes will be in Season 21 ofGreys Anatomy?

Will Ellen Pompeo come back for Season 21 ofGreys Anatomy?

Grey’s Anatomy tribute at the Emmy Awards

Shes always a huge part of the show; we have an open door policy with her.

Shes constantly in my head, her voice.

Who else will return inGreys AnatomySeason 21?

Deadlineexclusively reportedthat Jason George is rejoiningGreys Anatomyas a series regular for Season 21.

Scott Speedman, who plays Merediths love interest Nick Marsh,will be backin Season 21.

The show looks tocast a new gay malecharacter amid his exit.

Both Borelli and Francis will appear in multiple episodes in Season 21 to wrap their characters arcs.

Will there be new cast members forGreys AnatomySeason 21?

Sophia Bush hasjoined the castfor Season 21 in a recurring role.

Bush will play Dr. Cass Beckman, a fun and messy trauma surgeon at Seattle Presbyterian.

Her husband David Beckman, is a cardiothoracic surgeon at Grey Sloan.

Bushs character will first appear in episode 2106, which airs Nov. 7.

Julia Rose has beencast as Mika Yasudas(Midori Francis) sisters.

What happened in Season 20 ofGreys Anatomy?

Bailey challenged Foxs notion that she could replace anyone at any time.