Rosenworcels exit will allow Trump to appoint a third commissioner, giving Republicans a 3-2 majority.
Her five-year term on the commission was set to expire on June 30.
Rosenworcel has served on the commission since 2012.
Jessica RosenworcelSteven Ferdman/Getty Images
She also cited the launch of the first-ever Space Bureau at the agency.
An appellate court has stayed the rules as industry groups challenge their legal footing.