Rebecca Slaughter and Alvaro Bedoya said that they were illegally fired from their roles.
Traditionally, the commission has been split 3-2 favoring whichever party retains the White House.
No more than three commissioners can be of the same political party.
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The agency enforces consumer protection and competition laws.
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A White House spokesperson did not return a request for comment.
In a statement, Slaughter said that Trump violated federal statute and clear Supreme Court precedent.
Their firings raise questions of whether Trump also will make a run at remove Democrats from the FCC.
Slaughter said that if a president can remove FTC commissioners, he can remove members of the Fed.
This is not just about the stability and law enforcement without fear or favor at the FTC.
Its about the stability of our institutional structures of government, including those that protect monetary policy.
Instead, Trump replaced Khan with Ferguson.
This is just a really devastating sign about what could be to come, Khan told reporters.
Reuters first reported on their firings.
Earlier today, Google announced an agreement to acquire the cybersecurity firm Wiz for $32 billion.
The transaction is subject to the green light from the Justice Department and FTC.
Illegally gutting the Commission empowers fraudsters and monopolists, and consumers will pay the price.
Statement by illegally fired FTC commissioner@RKSlaughterFTCpic.twitter.com/JOwsaFsZq4
I am a commissioner at the Federal Trade Commission.
The president just illegally fired me.
This is corruption plain and simple.
