Alex Garcia Lopez and Laura Mora co-direct the project, which is produced by Colombian production company Dynamo.
Writers are Jose Rivera, Natalia Santa, Camila Bruges, Maria Camila Arias and Albatros Gonzalez.
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It wasrevealed in 2019that Netflix had landed rights to adapt the book.
Published in 1967,One Hundred Years of Solitudeis considered a masterpiece of Spanish-American and universal literature.
It has sold more than 50 million copies and has been translated into more than 40 languages.
